TABLE 2.
Multivariable logistic regression of constipation, fecal incontinence, and major LARS
| Variables | Constipation | Fecal incontinence | Major LARS | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
| Anastomotic height, cm | 1.08 (1.02–1.15) | 0.011* | 0.91 (0.85–0.98) | 0.010* | 0.93 (0.87–0.99) | 0.032* |
| Sex | ||||||
| Male | Reference | Reference | Reference | |||
| Female | 1.22 (0.84–1.77) | 0.302 | 0.74 (0.48–1.14) | 0.169 | 0.79 (0.51–1.21) | 0.279 |
| Age at surgery, y | 0.99 (0.97–1.01) | 0.250 | 1.00 (0.98–1.02) | 0.976 | 1.00 (0.98–1.02) | 0.987 |
| Follow-up, mo | 1.00 (0.99–1.01) | 0.776 | 1.00 (0.99–1.01) | 0.836 | 1.00 (0.99–1.01) | 0.908 |
| ASA score at surgery | 1.43 (1.05–1.95) | 0.022* | 0.81 (0.57–1.14) | 0.228 | ||
| Previous lower abdominal surgery | ||||||
| No | Reference | |||||
| Yes | 1.47 (0.94–2.30) | 0.094 | ||||
| Radiotherapy | ||||||
| No | Reference | Reference | Reference | |||
| Neoadjuvant short-course | 0.93 (0.55–1.57) | 0.791 | 2.60 (1.49–4.54) | 0.001** | 3.41 (2.00–5.86) | <0.001** |
| Neoadjuvant long-course | 0.88 (0.47–1.65) | 0.699 | 2.64 (1.40–4.97) | 0.003** | 2.02 (1.09–3.73) | 0.025* |
| Adjuvant chemotherapy | ||||||
| No | Reference | Reference | ||||
| Yes | 1.24 (0.77–1.99) | 0.383 | 0.82 (0.44–1.51) | 0.513 | ||
| Setting | ||||||
| Elective | Reference | |||||
| Emergency | 0.40 (0.05–3.27) | 0.395 | ||||
| Surgical approach | ||||||
| Open | Reference | Reference | Reference | |||
| Laparoscopic | 1.49 (0.99–2.26) | 0.058 | 0.79 (0.51–1.22) | 0.288 | 0.85 (0.55–1.33) | 0.481 |
| Conversion | 0.97 (0.46–2.05) | 0.940 | 0.84 (0.38–1.84) | 0.667 | 1.04 (0.49–2.20) | 0.914 |
| Method of anastomosis | ||||||
| Hand-sewn | Reference | |||||
| Stapled | 2.70 (0.57–12.87) | 0.212 | ||||
| Temporary stoma | ||||||
| No | Reference | Reference | Reference | |||
| Yes | 1.08 (0.67–1.75) | 0.749 | 0.94 (0.56–1.61) | 0.843 | 1.57 (0.93–2.64) | 0.091 |
| Anastomotic leakage | ||||||
| No | Reference | Reference | ||||
| Yes | 2.17 (1.03–4.56) | 0.041* | 1.31 (0.60–2.87) | 0.497 | ||
*
Statistical significance of p < 0.05.
** Statistical significance of p < 0.005.
LARS = low anterior resection syndrome.