Table II.
Accuracy of diagnostic techniques for the diagnosis of SARS-CoV-2 infection.
| Diagnostic test (Refs.) Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) (46) | Sensitivity (Refs.) 73.3-97.2% (respiratory tract samples) 0-24.1% (other specimens) 60.2-97.9% (PCR protocol) (44) | Specificity (Refs.) 90-100% (depending on sample type) (44) | ||
|---|---|---|---|---|
| Antibody tests (126) | 1st week | 2nd week | 3rd week | |
| IgG | 29.7% (95% CI, 22.1-38.6%) | 66.5% (95% CI, 57.9-74.2%) | 88.2% (95% CI, 83.5-91.8%) | 99.1% (95% CI, 98.3-99.6%) |
| IgM | 23.2% (95% CI, 14.9-34.2%) | 58.4% (95% CI, 45.5-70.3%) | 75.4% (95% CI, 64.3-83.8%) | 98.7% (95% CI, 97.4-99.3%) |
| IgG/IgM | 30.1% (95% CI, 21.4-40.7%) | 72.2% (95% CI, 63.5-79.5) | 91.4% (95% CI, 87-94.4%) | 98.7% (95% CI, 97.2-99.4%) |
| Rapid tests (125) | ||||
| Molecular-based tests (126) | 95.2% (95% CI, 86.7-98.3%) | 98.9% (95% CI, 97.3-99.5%) | ||
| Antigen-based tests (126) | 56.2% (95% CI, 29.5-79.8%) | 99.5% (95% CI, 98.1-99.9%) | ||
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.