Table 2.
Summary of the correlation between SMAD7 polymorphisms and CRC risk in five models.
| SNPs | Dominant model | Recessive model | Homozygous model | Heterozygous model | Additive model | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P/I2 (%) | OR (95% CI) | P/I2 (%) | OR (95% CI) | P/I2 (%) | OR (95% CI) | P/I2 (%) | OR (95% CI) | P/I2 (%) | |
| rs4939827 (T > C) | CC + CT vs TT | CC vs CT + TT | CC vs TT | CT vs TT | C vs T | |||||
| Removel unHWE | 0.89 (0.83,0.97) | <0.01/80.2% | 0.89 (0.83,0.96) | <0.01/78.4% | 0.84 (0.76,0.93) | <0.01/82.6% | 0.91 (0.85,0.97) | <0.01/68.3% | 0.91 (0.87,0.96) | <0.01/84.7% |
| Include unHWE | 0.89 (0.77,1.04) | <0.01/95.5% | 0.91 (0.85,0.97) | <0.01/78.1% | 0.85 (0.77,0.94) | <0.01/81.2% | 0.90 (0.85,0.96) | <0.01/66.6% | 0.94 (0.88,0.99) | <0.01/88.4% |
| Subgroup # | ||||||||||
| Ethnicity | ||||||||||
| Caucasian | 0.87 (0.8,0.94) | <0.01/80.3% | 0.87 (0.79,0.95) | <0.01/80.7% | 0.79 (0.7,0.89) | <0.01/85.3% | 0.88 (0.83,0.94) | <0.01/64.3% | 0.89 (0.84,0.95) | <0.01/85.3% |
| Asian | 0.99 (0.82,1.2) | <0.01/71.0% | 0.93 (0.82,1.04) | <0.01/73.2% | 0.98 (0.79,1.21) | <0.01/68.2% | 1.04 (0.88,1.23) | 0.01/60.4% | 0.95 (0.85,1.07) | <0.01/85.1% |
| African | 1.08 (0.79,1.48) | –/– | 1.06 (0.88,1.28) | –/– | 1.11 (0.8,1.54) | –/– | 1.05 (0.76,1.46) | –/– | 1.05 (0.91,1.21) | –/– |
| Mixed | 0.92 (0.71,1.48) | –/– | 1.12 (0.86,1.47) | –/– | 1.03 (0.75,1.42) | –/– | 0.87 (0.67,1.14) | –/– | 1.01 (0.86,1.18) | –/– |
| Control source | ||||||||||
| PB | 0.82 (0.76,0.89) | 0.474/0.0% | 0.90 (0.82,0.99) | 0.014/55.0% | 0.80 (0.71,0.92) | 0.082/40.0% | 0.85 (0.78,0.92) | 0.672/0.0% | 0.9 (0.84,0.96) | 0.016/54.1% |
| HB | 1.09 (0.94,1.27) | <0.01/77.5% | 0.99 (0.85,1.15) | <0.01/82.3% | 1.07 (0.88,1.31) | <0.01/81.6% | 1.05 (0.92,1.19) | <0.01/65.8% | 1.0 (0.9,1.1) | <0.01/84.1% |
| Mixed | 0.77 (0.66,0.89) | –/– | 0.89 (0.76,1.04) | –/– | 0.81 (0.67,0.97) | –/– | 0.86 (0.73,1.00) | –/– | 0.89 (0.82,0.98) | –/– |
| NA | 0.83 (0.75,0.93) | <0.01/84.1% | 0.81 (0.74,0.88) | <0.01/64.6% | 0.73 (0.65,0.83) | <0.01/76.3% | 0.87 (0.79,0.96) | <0.01/77.7% | 0.87 (0.8,0.93) | <0.01/85.3% |
| Sample scale | ||||||||||
| LARGE | 0.90 (0.83, 0.97) | <0.01/82.8% | 0.88 (0.82, 0.95) | <0.01/81.4% | 0.84 (0.76, 0.93) | <0.01/86.9% | 0.92 (0.86, 0.98) | <0.01/73.4% | 0.91 (0.87, 0.96) | <0.01/86.4% |
| SMALL | 0.85 (0.62, 1.18) | <0.01/67.2% | 0.96 (0.74, 1.23) | <0.01/60.8% | 0.82 (0.67, 1.02) | <0.01/70.1% | 0.89 (0.72, 1.1) | <0.01/50.3% | 0.92 (0.7, 1.23) | 0.09/50.2% |
| rs4464148 (T > C) | CC + CT vs TT | CC vs CT + TT | CC vs TT | CT vs TT | C vs T | |||||
| Removel unHWE | 1.17 (1.07, 1.27) | 0.058/45.3% | 1.22 (1.11, 1.22) | 0.404/3.9% | 1.29 (1.17, 1.42) | 0.286/17.1% | 1.13 (1.04, 1.24) | 0.040/48.8% | 1.14 (1.09, 1.29) | 0.100/38.7% |
| Include unHWE | 1.11 (1.00, 1.23) | <0.01/72.1% | 1.23 (1.14, 1.33) | 0.492/0.0% | 1.25 (1.15, 1.36) | 0.220/22.1% | 1.07 (0.95, 1.20) | <0.01/73.7% | 1.12 (1.05, 1.20) | <0.01/63.4% |
| Subgroup # | ||||||||||
| Ethnicity | ||||||||||
| Caucasian | 1.15 (1.06, 1.26) | 0.051/48.2% | 1.21 (1.11, 1.33) | 0.34/11.4% | 1.29 (1.17, 1.42) | 0.229/24.2% | 1.12 (1.02, 1.23) | 0.037/51.3% | 1.13 (1.09, 1.18) | 0.102/39.9% |
| Asian | 1.33 (1.02, 1.72) | –/– | 1.75 (0.51, 6.01) | –/– | 1.82 (0.53, 6.25) | –/– | 1.31 (1.01, 1.71) | –/– | 1.32 (1.03, 1.68) | –/– |
| Control source | ||||||||||
| PB | 1.11 (0.95, 1.31) | 0.138/49.5% | 1.11 (0.93, 1.32) | 0.307/15.3% | 1.17 (0.97, 1.41) | 0.156/46.2% | 1.12 (0.97, 1.29) | 0.233/31.4% | 1.10 (1.01, 1.2) | 0.098/56.9% |
| HB | 1.12 (0.72, 1.75) | 0.039/69.3% | 1.69 (1.03, 2.76) | 0.639/0.0% | 1.52 (0.91, 2.55) | 0.894/0.0% | 1.07 (0.59, 1.96) | <0.01/81.3% | 1.17 (0.98, 1.4) | 0.316/13.2% |
| NA | 1.20 (1.09, 1.33) | 0.134/46.3% | 1.24 (1.11, 1.39) | 0.361/6.4% | 1.33 (1.18, 1.49) | 0.162/41.6% | 1.15 (1.07, 1.25) | 0.316/15.2% | 1.14 (1.1, 1.19) | 0.058/56.1% |
| Sample scale | ||||||||||
| LARGE | 1.18 (1.10, 1.27) | 0.151/34.8% | 1.21 (1.10, 1.32) | 0.419/1.3% | 1.27 (1.15, 1.41) | 0.12/40.7% | 1.15 (1.09, 1.23) | 0.379/6.3% | 1.14 (1.1, 1.19) | 0.058/48.6% |
| SMALL | 1.03 (0.49, 2.18) | 0.117/59.4% | 1.67 (0.98, 2.87) | 0.345/0.0% | 1.48 (1.03, 2.11) | 0.94/0.0% | 0.99 (0.35, 2.84) | 0.04/76.2% | 1.03 (0.8, 1.33) | 0.482/38.7% |
| rs12953717 (C > T) | TT + TC vs CC | TT vs CC + TC | TT vs CC | TC vs CC | T vs C | |||||
| Removel unHWE | 1.11 (1.01, 1.22) | <0.01/76.7% | 1.22 (1.15, 1.28) | 0.209/22.0% | 1.25 (1.13, 1.38) | <0.01/55.3% | 1.06 (0.96, 1.18) | <0.01/77.2% | 1.11 (1.05, 1.17) | <0.01/67.0% |
| Include unHWE | 1.08 (0.98, 1.18) | <0.01/76.4% | 1.17 (1.07, 1.28) | <0.01/60.4% | 1.18 (1.05, 1.33) | <0.01/70.9% | 1.06 (0.97, 1.17) | <0.01/73.3% | 1.08 (1.01, 1.15) | <0.01/75.7% |
| Subgroup # | ||||||||||
| Ethnicity | ||||||||||
| Caucasian | 1.13 (1.01, 1.28) | <0.01/78.1% | 1.26 (1.19, 1.34) | 0.620/0.0% | 1.34 (1.21, 1.48) | 0.053/46.2% | 1.07 (0.94, 1.21) | <0.01/79.1% | 1.14 (1.071.22) | <0.01/66.8% |
| Asian | 1.32 (0.83, 2.11) | 0.048/74.4% | 1.00 (0.73, 1.37) | 0.17/46.9% | 1.08 (0.79, 1.49) | 0.426/0.0% | 1.4 (0.78, 2.53) | 0.017/82.4% | 1.10 (0.97, 1.24) | 0.337/0.0% |
| African | 1.12 (0.93, 1.35) | –/– | 1.17 (0.83, 1.65) | –/– | 1.22 (0.85, 1.74) | –/– | 1.10 (0.91, 1.34) | –/– | 1.1 (0.95, 1.28) | –/– |
| Mixed | 0.92 (0.78, 1.10) | 0.175/45.7% | 1.05 (0.92, 1.20) | 0.306/4.6% | 1.0 (0.86, 1.16) | 0.959/0.0% | 0.88 (0.68, 1.13) | 0.07/69.6% | 0.99 (0.92, 1.07) | 0.739/0.0% |
| Control source | ||||||||||
| PB | 1.09 (0.88, 1.35) | 0.019/70.0% | 1.16 (1.0, 1.34) | 0.406/0.0% | 1.14 (0.97, 1.35) | 0.562/0.0% | 1.08 (0.83, 1.41) | <0.01/78.5% | 1.07 (0.99, 1.16) | 0.363/6.1% |
| HB | 1.0 (0.75, 1.34) | <0.01/88.8% | 1.3 (1.17, 1.44) | 0.698/0.0% | 1.23 (0.97, 1.57) | 0.026/63.7% | 0.93 (0.67, 1.28) | <0.01/89.8% | 1.07 (0.91, 1.25) | <0.01/81.0% |
| Mixed | 1.16 (1.01, 1.34) | –/– | 1.3 (1.09, 1.54) | –/– | 1.36 (1.13, 1.65) | –/– | 1.09 (0.94, 1.27) | –/– | 1.16 (1.06, 1.28) | –/– |
| NA | 1.17 (1.04, 1.32) | 0.015/67.8% | 1.18 (1.10, 1.27) | 0.048/58.3% | 1.28 (1.07, 1.54) | <0.01/74.3% | 1.12 (1.02, 1.23) | 0.132/43.5% | 1.13 (1.04, 1.24) | <0.01/75.2% |
| Sample scale | ||||||||||
| LARGE | 1.17 (1.10, 1.25) | 0.073/42.8% | 1.21 (1.15, 1.28) | 0.339/10.8% | 1.26 (1.13, 1.41) | 0.046/55.7% | 1.12 (1.07, 1.17) | <0.01/0.0% | 1.11 (1.04, 1.17) | <0.01/71.2% |
| SMALL | 0.93 (0.63, 1.4) | <0.01/85.1% | 1.42 (1.03, 1.97) | 0.103/56.1% | 1.21 (1.0, 1.47) | 0.01/60.0% | 0.96 (0.62, 1.47) | <0.01/89.7% | 1.27 (0.94, 1.72) | 0.888/0.0% |
Bold font indicates statistically significant results.
CRC = colorectal cancer, HB = hospital based, HWE = Hardy-Weinberg equilibrium, LARGER = the total sample size in the study was greater than 1000, Mixed (control source) = the control group was derived from both PB and HB, Mixed (ethnicity) = Study subjects belong to two or more races that cannot be grouped together, NA = the source of the control group was unclear, PB = population based, SMAD7 = Sma-and Mad-Related Protein 7, SMALL = the total sample size in the study was less than 1000, unHWE = Not in accordance with the Hardy-Weinberg equilibrium study.
#, Data for subgroup analysis were obtained from the excluded unHWE study.