Table 2.

Effects of desformylflustrabromine on motor coordination in CCI-performed mice.

Dose of nicotine	Saline	dFBr (9 mg/kg)
0 mg/kg (saline)	2.050 ± 0.846	4.433 ± 1.377
1.5 mg/kg	74.633 ± 1.794 *	7.750 ± 1.544 #

Desformylflustrabromine (dFBr) and nicotine were tested for possible motor impairment in CCI-operated mice after 2 weeks of surgery. Mice received dFBr (9 mg/kg, subcutaneously) or saline, and 15 min later mice were given a subcutaneous injection of nicotine (1.5 mg/kg) or saline as vehicle. Mice were placed on the rotarod 5 min after last injection. Data reflect mean ± SEM, n = 6 mice/group, as time to fall in % impairment for each group.

^*P < 0.05 vs saline-saline treatment.

^#P < 0.05 vs saline-nicotine treatment.