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Endoglycosidase catabolism of CS chains. Several endoglycosidase degradation enzymes can cleave CS chains. Each enzyme has preferred CS substrates with HYAL1 and SPAM1 typically cleaving C4S (CS-A) units, HYAL4/CHSE cleaving at C2,6S (CS-D) units, and less avidly C6S (CS-C). No specific endoglycosidase for DS has been discovered to date. CS, chondroitin sulfate; DS, dermatan sulfate.
