Table 1.
CSPG and CS/DS associated enzyme RNA-Seq transcripts detected in healthy skeletal muscle (with a medium TPM above 1) and in DMD muscle [upregulated 5-fold, italic; 1.5-fold, bold; downregulated, underlined; *data from (47)]
| Healthy Skeletal Muscle Genes |
DMD Muscle Genes |
||
|---|---|---|---|
| CSPGs | CS/DS Enzymes | CSPGs | CS/DS Enzymes |
| CD99L2 | CSGALNACT1 | CD74 | CHPF |
| CD74 | CSGALNACT2 | LAMA4 | DES2/DSEL |
| DCN | CHSY1 | VCAN | CHST13 |
| BGN | CHPF | CD44 | CHST11* |
| SRGN | CHPF2 | BGN | HYAL4/CHSE* |
| CSPG4 | CHST7 | SRPX | |
| HSPG2 | CHST10 | SPP1 | |
| SULF2 | CHST12 | SULF2 | |
| CD44 | CHST13 | ||
| TGFBR3 | CHST14 | ||
| THBD | CHST15 | ||
| SPOCK1 | UST | ||
| SRPX | DSE | ||
| SRPX2 | HYAL1 | ||
| LAMA4 | HYAL4/CHSE | ||
| SDC3 | HEXA | ||
| PLXDC1 | HEXB | ||
| LAMC2 | |||
| NID2 | |||
| RARRES1 | |||
| VCAN | |||
Healthy skeletal muscle data were obtained from Genotype-Tissue Expression (GTEx) project (V8). DMD skeletal muscle data obtained from previous studies (47–49). CS/DS, chondroitin sulfate/dermatan sulfate; CSPGs, chondroitin sulfate proteoglycans; DMD, Duchenne muscular dystrophy; TPM, transcripts per million.