Figure 2.

Transcriptomic differences in neonates with bronchopulmonary dysplasia (BPD) and control subjects (no BPD). A: volcano plot demonstrating log fold differences in genes with a false discovery rate <5%. Purple dots designate differentially expressed genes, whereas dots in yellow denote no difference. B: boxplots of the top 14 genes by BPD (n = 62 subjects) vs. no BPD (n = 35). Each box indicates the median with interquartile range, whereas the dots represent expression of the gene per individual. ABTB2, ankyrin repeat and BTB domain containing 2; AK5, adenylate kinase 5; AKT3, AKT serine/threonine kinase 3; AURKB, Aurora kinase B; CD4, CD4 molecule; CTSO, Cathepsin O; MSANTD2, Myb/SANT DNA binding domain containing 2; P2RX7, purinergic receptor P2X, ligand-gated ion channel 7; PNPO, pyridoxine 5′-phosphate oxidase; PTGFRN, Prostaglandin F2 receptor inhibitor; RRM2, ribonucleotide reductase regulatory subunit M2; SNX1, sorting nexin 1; SPON1, Spondin 1; WDR73, WD repeat domain 73. PDA, patent ductus arteriosus.