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. 2022 Dec 15;26(1):53–63. doi: 10.1038/s41593-022-01213-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Gene expression brain maps of serotonin receptor genes are combined with fMRI (both mouse and human) via FSL DR to map temporal and spatial fMRI signatures of different serotonin receptor types. a, DR-stage 1: regresses the spatial maps of serotonin receptor genes into each subject’s four-dimensional (4D) fMRI dataset. This gives a subject-specific time-course quantifying network amplitude changes for each SRN. DR-stage 1 can be used to address questions such as: What are the SRN amplitude changes in response to optogenetic stimulation? b, DR-stage 2: regresses subject-specific time-courses into the same 4D fMRI dataset. This provides a subject-specific spatial map quantifying functional connectivity for each SRN. DR-stage 2 can be used to address questions such as: What are the SRN brain correlates associated with individual differences in a depression scale? Sub, subject.