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. 2022 Dec 15;26(1):53–63. doi: 10.1038/s41593-022-01213-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Related to Fig. 3. a) Results from permutation analysis of linear models for group differences between the ChR2 group treated with fluoxetine and the control group in SRN time-locked amplitude changes. Statistical significance was assessed with 1,000 block-aware permutations (whilst allowing permutations only within-subject), with FWE-corr for multiple comparisons. Showing -log10 FWE-corr p-values, corrected across time and two tails. Dashed lines demark statistical thresholds. b) Showing negative correlations between Htr1a and Htr4 SRN activity. Correlation assessed via one-tail Spearman’s correlation. Left: scatter plot relating fluoxetine-induced changes in Htr1a and Htr4 SRN amplitude during ofMRI experiments. Right: scatter plot relating fluoxetine-induced peak activity in Htr1a and Htr4 SRN amplitude across subjects. For both left and right scatter plots, fluoxetine-induced changes are fluoxetine + ChR2 minus ChR2 only ofMRI amplitude changes.