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. 2022 Dec 12;26(1):27–38. doi: 10.1038/s41593-022-01207-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a, b. Detection of by Cas13d-HA via HA immunostaining (red) 3 weeks post-intrastriatal injection of AAV9-Cas13d/CAG^EX. Scale bar = 900 µm (b). c, d. Western blot analysis of wild type HTT (wtHTT, antibody MAB 2166 antibody). There are no significant differences between two groups by a one-sided Student’s t-test (n = 4 mice/group, 2 female and 2 male per group, 11 weeks of age). e, f. Full images of western blots shown in Fig. 5e, f.

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