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. 2022 Dec 19;26(1):12–26. doi: 10.1038/s41593-022-01221-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, Schema for positive selection genome-wide CRISPR screen in Cas9-expressing human immortalized microglia. Illustrations were created with BioRender. b,e, Scatter plot of overlapping hits from each viral pool after 8-hour exposure (b) or 24-hour exposure (e). Genes highlighted in green were identified in at least one of the GO-associated pathways. Statistical analysis was performed by MAGeCK. ACSL4 and SEC24B are highlighted in red as the two genes identified across both timepoints and viral pools. c,d, Top associated pathways determined by GO biological process (c) and GO cellular component (d) for 8-hour exposure. f,g, Top associated pathways determined by GO biological process (f) and GO cellular component (g) for 24-hour exposure. Fisher exact test was performed for all pathway analyses.