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. 2022 Dec 19;26(1):12–26. doi: 10.1038/s41593-022-01221-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, Schema and results for pharmacological compound screen in which 546 compounds were tested for their ability to block ferroptosis in an immortalized microglia cell line. Illustrations were created with BioRender. b, Thirty-nine of the 546 compounds rescued cell viability to at least 70% of the vehicle control (blue dots), and five rescued to at least 100%. Three technical replicates per compound. Red line indicates average cell survival with ferroptosis induction and no compound. c, Heat map of percent cell survival for the 39 hits and the Selleck-associated pathway or function. d, Heat map of percent cell survival for compounds predicted to interact with GPCR signaling, PI3K signaling or necroptosis by ChEMBL. e, Correlation between the targets of pharmacological hits and genes identified in the CRISPR screen that are associated with the targets, separated by general pathway/function. Illustrations were created with BioRender.