. 2022 Dec 4;17(1):3–12. doi: 10.1111/crj.13559

TABLE 2.

Sample characteristics and aspects related to the diagnosis of exercise‐induced bronchospasm

Author, place and year	EIB on objective	Sample			Protocol for EIB diagnosis
		N	Age	Public	Bronchial provocation test performed	Exercise intensity	Post‐test evaluation								Diagnostic
		N	Age	Public	Bronchial provocation test performed	Exercise intensity	<5′	5′	7,5′	10′	15′	20′	30′	45′	Diagnostic
Neder et al. 1999 ²⁴ Brazil ^a	No	24	6 à 17 years	Moderate to severe asthma	Pré: Spirometry—6‐min test on the treadmill	80% MCF (220‐age). 1 min to get max.		X		X		X			∆FEV₁ > 10%
Matsumoto et al. 1999 ²⁸ Japan ^b	Yes	16	8 à 12 years	Asthmatics	Pré: Spirometry—6‐min swim test and cycle ergometer	175% and 100% of the lactate threshold.		X			X				∆FEV₁ > 10%
Veldhoven et al. 2001 ²⁵ Netherlands ^c	No	47	8 à 13 years	Moderate to severe asthma	Pré: Spirometry—6‐min test on the treadmill	20–30 beats lower than predicted (220‐age)	X		X	X					∆FEV₁ > 10%
Natali ²⁹ et al. 2002 Brazil ^d	Yes	32	10 à 16 years	Asthmatics	Pré: Spirometry—6‐min test on the treadmill	85%–90% MCF (220‐age). 2 min to get max.		X							∆MEF₁ > 10%–15%
Silva ²⁶ et al. 2006 Brazil	No	69	8 à 11 years	Asthma Moderate/persistent	Pré: Spirometry—6‐min test on the treadmill	80% MCF (220‐age) 1 min to get max.		X		X	X	X	X	X	∆FEV₁ > 10%
Faneli ³⁰ et al. 2007 Brazil ^e	Yes	38	7 à 15 years	Moderate to severe asthma	Pré: Spirometry—6‐min test on the treadmill	80% MCF. 4 min to get max.		X		X		X			∆FEV₁ > 10%
Sidiropoulou ²⁷ et al. 2007 Greece	Yes	29	9 à 16 years	Athletes with EIB	Pré: Spirometry—6‐min test on the treadmill	80%–90% MCF.	X	X		X	X	X	X		∆FEV₁ > 10%
Tahan ²³ et al. 2014 Turkey ^f	Yes	24	6 à 17 years	Moderate asthma	Pré: Spirometry—6‐min test on the treadmill	90% MCF (220‐age) 1 min to get max.		X		X	X	X			∆FEV₁ > 15%

Note: Superscript lines indicate possible limitations found in the methodology of the studies found. MCF = Maxima Cardiac Frequency. MEF = Maximum Expiratory Flow. FEV1 = Forced Expiratory Volume in the first second. Taxed = studies that followed the recommendations for exercise‐induced bronchospasm (EIB) assessment.

^{^a}

Study analyzes groups with a non‐homogeneous sample in the selection of subjects and in FEV₁.

^{^b}

Effort prescription was by lactate threshold.

^{^c}

Does not show spirometry values after 10 min.

^{^d}

Diagnosis of EIB through maximum expiratory flow (MEF).

^{^e}

Does not show spirometry after 20 min.

^{^f}

Study does not define its control group adequately.