FIG. 5.

Inflammatory response of human intestinal xenografts to E. histolytica is inhibited by treatment with indomethacin (Indo; 1.5 mg/kg every 8 h) or NS-398 (1 mg/kg every 8 h). Xenografts were harvested 24 h after infection with E. histolytica or sham infection with media alone. MPO activity was measured as described in Materials and Methods. Data are means ± standard errors of the means for 4 to 12 xenografts. ∗, P < 0.001 compared with uninfected xenograft; ∗∗, P < 0.001 compared with E. histolytica alone.