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Zoledronic acid declines the population of PGCCs pre- and post-cisplatin administration. (A) DNA content analysis of 5637 bladder cancer cells treated with different doses of ZA indicates the reduction of PGCCs post-treatment. (B) Cisplatin administration enriches PGCCs and ZA at different doses from 10–600 μM declines the PGCC population with the most profound effect being observed at 50 μM. *p-value < 0.05; ** p- value < 0.01; error bars: mean ± SEM.
