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. 2023 Jan 9;13:419. doi: 10.1038/s41598-022-27090-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PGCCs have augmented lipid metabolism. (A) Oil Red O staining demonstrated the accumulation of lipid droplets in PGCCs surviving after cisplatin treatment which partly declined after ZA treatment. Nuclei are stained with haematoxylin. (B) Quantification of the red signals in the images of Oil Red O-stained cells in three independent experiments confirmed the microscopic observations. (C) Total cholesterol content of cancer cells increased after cisplatin treatment. * p-value < 0.05; error bars: mean ± SEM.