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. 2023 Jan 9;14:128. doi: 10.1038/s41467-023-35790-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative structure of a GPCR with the seven transmembrane (TM) helices viewed side on (left) and from the extracellular side (right). b One-dimensional free energy (FE) profiles of the 45 GPCRs as a function of the reaction coordinate, the fraction of structured blocks, at the melting temperature. The more folded conformations populate to the right of the free energy profile (high reaction coordinate values), while the partially structured states and unfolded conformations will be populated to the left (intermediate and low reaction coordinate values, respectively). The numbers on the top left of every panel are the GPCR indices. c The number of intermediates determined from the free energy profiles in panel b assuming a 1RT threshold. Source data are provided as a Source data file.