TABLE 2.
Reactivities of several MAbs and 12A1→13F1 variants with peptide mimotopes of GXM
| Antibody | Reactivitya with peptide:
|
|||
|---|---|---|---|---|
| PA1 | 601 | 206.1 | PM14 | |
| 2D10 | + | +++ | +++ | + |
| 2H1 | +++ | ++ | +++ | + |
| 21D2 | − | − | +++ | − |
| 12A1 | − | − | + | − |
| 13F1 | − | − | − | +++ |
| 12A1VH-13F1VL | − | − | + | − |
| 12A1VH-13F1VL | − | − | + | − |
| N31S | − | − | − | − |
| F33Y | − | − | − | ++ |
| M50A | − | − | − | − |
| I53S | − | − | ++ | − |
| N56G | − | − | +++ | − |
| N57S | − | − | − | − |
| D80Y | − | − | +++ | − |
| F103Y | − | − | − | − |
| F33Y N57S | − | − | − | − |
a
Plus and minus signs indicate the relative reactivities of the various Abs for the peptide as measured by ELISA, ranging from none (−) to weak (+) to strong (+++).