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. 2023 Jan 9;14:120. doi: 10.1038/s41467-022-35584-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Schematic depicting IRE1α signature generation and evaluation. b Kaplan–Meier survival plots depicting associations between overall survival (OS) and IRE1α^KO signature status in human TCGA-LUAD. High is top 1/3rd (n = 166) and low is bottom 1/3^rd (n = 165) of the IRE1α^KO signature scores. HR is the hazard ratio and p adj is log-rank p value from the multivariate Cox proportional-hazards regression model. c Gene ontologies between the IRE1α^KO signature high and low tertile patients. The count of genes enriching the term on the top x-axis is represented as a barplot, and the –log(10) p value for the terms on the bottom x-axis, represented as a black symbol. Exact P values are in the Source Data file. d–n Violin plots of xCell pipeline enrichment scores for microenvironment (d P < 0.0001), immune (e P < 0.0001), stromal (f P < 0.0001), DC (g P < 0.0001) cDC (h P < 0.0001), pDC (i P < 0.0001), CD8 + T cells (j P < 0.0001), Effector CD8 T cells (k P = 0.0011), CD4 T cells (l P = 0.0013), Effector CD4 T cells (m P = 0.0017), and Treg (n P < 0.0001) from the top and bottom tertiles of those with high (red, n = 169) or low (blue, n = 169) signature enrichment. Unpaired Student’s t-test, two-sided. *P < 0.05, **P < 0.001, and ***P < 0.0001. Source data are provided as a Source Data file.