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. 2023 Jan 9;14:118. doi: 10.1038/s41467-022-35753-w

Fig. 2. CSF1R inhibition extends survival of female Tg2541 mice.

Fig. 2

a Schematic of terminal PLX3397 treatment (275 mg/kg oral) of Tg2541 mice from 2 mo of age until death. b Kaplan–Meier plot showing percent survival of female or male Tg2541 mice treated with vehicle or PLX3397. n = 7 mice for Female Vehicle; n = 6 mice for Female PLX3397; n = 9 mice for Male Vehicle; n = 9 mice for Male PLX3397. c Body weights of female or male Tg2541 mice treated with vehicle or PLX3397. Differences in weight between vehicle and PLX3397 treatment in female or male mice were evaluated by mixed-effects analysis (Restricted maximum likelihood). Each symbol represents an individual mouse and lines indicate group means. d, e Correlation plots for body weight at 180 d of age (d) or forebrain tau-prion activity at death (e) and survival for female or male Tg2541 mice treated with vehicle or PLX3397. Each symbol represents an individual mouse and linear regression lines are shown for female or male mice, with vehicle- and PLX3397-treated mice combined. Pearson’s correlation analysis was performed and the results are shown. f Schematic of terminal PLX3397 treatment of Tg2541 mice from 2.5 mo of age until death, following inoculation of K18 tau fibrils into the midbrain (hindbrain region) at 2.5 mo of age. g Kaplan–Meier plot showing percent survival of female or male Tg2541 mice inoculated with K18 tau fibrils or diluent. n = 8 mice for Female Vehicle Diluent; n = 7 mice for Female Vehicle K18; n = 8 mice for Male Vehicle Diluent; n = 7 mice for Male Vehicle K18. Differences in survival between diluent and K18 inoculation in male or female mice treated with vehicle were evaluated by Log-rank (Mantel-Cox) test. h Kaplan–Meier plot showing percent survival of female or male Tg2541 mice inoculated with K18 tau fibrils and then receiving terminal treatment of vehicle or PLX3397 (275 mg/kg oral). n = 7 mice for Female Vehicle K18; n = 6 mice for Female PLX3397 K18; n = 7 mice for Male Vehicle K18; n = 8 mice for Male PLX3397 K18. In (b, g, and h), differences in survival between treatment groups were evaluated by Log-rank (Mantel-Cox) test. Source data are provided as a Source Data file.