Table 2.
Test accuracy of individual studies and pooled results from meta-analysis.
| Outcome (95% CI) | Outcome (95% CI) | |||||
|---|---|---|---|---|---|---|
| OCTA compared to FA | ||||||
| Individual studiesa | TP | FP | FN | TN | Sensitivity | Specificity |
| Bagchi 2019 | 19 | 1 | 4 | 3 | 0.83 (0.61–0.95) | 0.75 (0.19–0.99) |
| Miyata 2016 | 16 | 0 | 1 | 4 | 0.94 (0.71–1.00) | 1.00 (0.40–1.00) |
| Querques 2017 | 19 | 2 | 2 | 30 | 0.90 (0.70–0.99) | 0.94 (0.79–0.99) |
| Pooled results from meta-analysisb | Sensitivity | Specificity | ||||
| 0.89 (0.78–0.94) | 0.93 (0.79–0.98) | |||||
| LR of a positive test | LR of a negative test | |||||
| 11.8 (3.96–35.25) | 0.12 (0.061–0.25) | |||||
| Positive PV | Negative PV | |||||
| 0.95 (0.79–0.99) | 0.85 (0.61–0.94) | |||||
| SD-OCT compared to FA | ||||||
| Individual studiesa | TP | FP | FN | TN | Sensitivity | Specificity |
| Bagchi 2019 | 23 | 4 | 0 | 0 | 1.00 (0.85–1.00) | 0.00 (0.00–0.60) |
| Milani 2016 | 48 | 0 | 1 | 16 | 0.98 (0.89–1.00) | 1.00 (0.79–1.00) |
| Su 2014 | 16 | 0 | 0 | 53 | 1.00 (0.79–1.00) | 1.00 (0.93–1.00) |
| Pooled results from meta-analysisb | Sensitivity | Specificity | ||||
| 0.99 (0.91–1.00) | unestimatable | |||||
| LR of a positive test | LR of a negative test | |||||
| unestimatable | 0.01 (0.001–0.095) | |||||
| Positive PV | Negative PV | |||||
| unestimatable | unestimatable | |||||
CI confidence interval, OCTA optical coherence tomography angiography, FA fluorescein angiography, TP true positive, FP false positive, FN false negative, TN true negative, LR likelihood ratio, PV predictive value, SD-OCT spectral domain optical coherence tomography.
aCalculated using RevMan Ver 5.4.1.
bCalculated using SAS macro MetaDAS v1.3.