. 2022 Dec 2;37(1):21–29. doi: 10.1038/s41433-022-02227-8

Table 3.

Key recommendations.

Test	Recommendation
OCTA	Conditionally recommend the use of OCTA to achieve a diagnosis when mCNV is clinically suspected. Statement was conditional because all studies excluded patients from analysis due to image quality issues. • Recommend OCTA as an initial screening study to rule out mCNV. • Recommend OCTA to rule in the presence of mCNV. However, due to a possible high false positive rate, a positive diagnosis should be confirmed by FA.
SD-OCT	Conditionally suggest clinicians may consider the use of SD-OCT to achieve a diagnosis when mCNV is clinically suspected. Statement was conditional because of the inability to estimate a pooled specificity for SD-OCT resulting in an unknown false positive rate. • Recommend SD-OCT as an initial screening study to rule out mCNV. • Do not recommend reliance on SD-OCT alone to rule in the presence of mCNV because the false positive rate of SD-OCT is unknown. A positive diagnosis must be confirmed by FA.
OCTA + SD-OCT	Clinicians may consider using SD-OCT if an OCTA image of sufficient quality cannot be acquired. • If either OCTA or SD-OCT return a negative result, clinicians may be fairly confident in ruling out mCNV. • If either OCTA or SD-OCT return a positive result, FA should be performed to rule out false positives and confirm the diagnosis.

Test

Recommendation

OCTA

Conditionally recommend the use of OCTA to achieve a diagnosis when mCNV is clinically suspected. Statement was conditional because all studies excluded patients from analysis due to image quality issues.

• Recommend OCTA as an initial screening study to rule out mCNV.

• Recommend OCTA to rule in the presence of mCNV. However, due to a possible high false positive rate, a positive diagnosis should be confirmed by FA.

SD-OCT

Conditionally suggest clinicians may consider the use of SD-OCT to achieve a diagnosis when mCNV is clinically suspected. Statement was conditional because of the inability to estimate a pooled specificity for SD-OCT resulting in an unknown false positive rate.

• Recommend SD-OCT as an initial screening study to rule out mCNV.

• Do not recommend reliance on SD-OCT alone to rule in the presence of mCNV because the false positive rate of SD-OCT is unknown. A positive diagnosis must be confirmed by FA.

OCTA + SD-OCT

Clinicians may consider using SD-OCT if an OCTA image of sufficient quality cannot be acquired.

• If either OCTA or SD-OCT return a negative result, clinicians may be fairly confident in ruling out mCNV.

• If either OCTA or SD-OCT return a positive result, FA should be performed to rule out false positives and confirm the diagnosis.

OCTA Optical coherence tomography angiography, mCNV Myopic choroidal neovascularisation, FA Fluorescein angiography, SD-OCT Spectral domain optical coherence tomography.