Table 1.

Unique Hallmarks of Extracellular Vesicles (EVs).

No.	Remarks	Reference
1	All the body cells studied to date produce EVs and are significantly more prevalent in bodily fluids than circulating tumor cells and circulating tumor DNA.	Allard et al,24 Fernando et al,25 Johnsen et al26
2	Tumor-derived EVs contain a range of compounds, including potentially tumor-specific biomarkers, showcasing their molecular fingerprint.	Hurwitz et al,27 Kucharzewska et al,28 Clos-Garcia et al29
3	EVs are quite stable under a variety of physiological conditions, preserving their contents (biomarkers) and facilitating the subsequent analysis.	Boukouris and Mathivanan30