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. 2022 Dec 14;28:129–145. doi: 10.1016/j.omtm.2022.12.007

Figure 2.

Figure 2

AAV5-hGRK1-GUCY2D significantly improves retinal function in GCDKO mice

Cone-mediated (photopic) and rod-mediated (scotopic) function were evaluated in GCDKO mice 1 month after subretinal injection with vector at low (1.5 × 1012 vg/mL) or high (1 × 1013 vg/mL) concentrations. This corresponds to doses of 1.5 × 109 and 1 × 1010 vg/eye, respectively. Statistically significant increases in photopic and scotopic b waves relative to untreated controls were observed. ∗∗∗∗p > 0.0001, as determined by multiple paired t tests with Holm-Sidak correction for multiple comparisons. n = 19 in the uninjected control groups at low and high doses; n = 20 in the AAV5-GUCY2D treated groups at low and high doses.