Table 1.

Results of the Bidirectional Transport of 6-MPNs and the Effects of Efflux Inhibitors on the Transport

Samples	Papp (× 10−6) (cm/s)		ER
	AP-BL	BL-AP
6-MPCs	1.952 ± 0.051*	0.313 ± 0.233	0.154 ± 0.113
6-MPNs	8.494 ± 1.447*	0.196 ± 0.039	0.023 ± 0.004
Indomethacin + 6-MPCs	1.780 ± 0.447	0.308 ± 0.116	0.138 ± 0.042
Indomethacin + 6-MPNs	2.800 ± 0.963*	0.249 ± 0.050	0.112 ± 0.046

Notes: each value represents the mean ± SD (n = 3), * P value < 0.05, 6-MPNs vs 6-MPCs or Indomethacin + 6-MPNs vs.6-MPNs.

Abbreviations: Papp, apparent permeability coefficient; ER, efflux ratio; AP-BL, from the AP sides to the BL sides; BL-AP, from the BL sides to the AP sides.