TABLE 1.
Scoring of cytokine and iNOS expression in sequential biopsies
| Patient | Classificationb
|
Scorea on indicated day of biopsy
|
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cell infiltrate
|
IFN-γ
|
IL-12
|
iNOS
|
||||||||||||||||
| Class | MDT | Clinical improvement (28 Days) | 0 | 7 | 28 | 180 | 0 | 7 | 28 | 180 | 0 | 7 | 28 | 180 | 0 | 7 | 28 | 180 | |
| 131 | BL-RR | Previously | Complete | 2 | 3 | 3 | 3 | 2 | 2 | 2 | 1 | 3 | 3 | 3 | 2 | 3 | 3 | 3 | |
| 141 | BL-RR | Yes | Partial | 3 | 2 | 1 | 2 | 2 | 2 | 1 | 3 | 2 | 2 | 3 | 3 | 2 | 2 | 3 | |
| 146 | BL-RR | No | Partial | 3 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 3 | 2 | 1 | ||||
| 186 | BL-RR | No | Complete | 2 | 1 | 1 | 2 | 2 | 0 | 2 | 2 | 1 | 2 | 2 | 1 | ||||
| 198 | BL-RR | No | Partial | 3 | 3 | 2 | 0 | 3 | 3 | 3 | 0 | 3 | 3 | 2 | 0 | 3 | 3 | 2 | 0 |
| 207 | BL-RR | No | Partial | 3 | 3 | 0 | 1 | 3 | 3 | 1 | 2 | 3 | 3 | 0 | 0 | 3 | 3 | 0 | 1 |
| 260 | BL-RR | Yes | Partial | 3 | 3 | 1 | 1 | 3 | 3 | 2 | 0 | 3 | 2 | 1 | 0 | 2 | 2 | 1 | 0 |
| 304 | BL-RR | No | Partial | 2 | 2 | 0 | 3 | 3 | 1 | 2 | 3 | 0 | 2 | 3 | 0 | ||||
| 343 | BL-RR | No | Partial | 1 | 2 | 0 | 3 | 3 | 0 | 3 | 3 | 0 | 3 | 3 | 0 | ||||
| 143 | BT-RR | No | Partial | 2 | 1 | 1 | 2 | 2 | 1 | 3 | 3 | 2 | 3 | 2 | 0 | ||||
| 162 | BT-RR | No | Partial | 3 | 2 | 2 | 3 | 3 | 2 | 3 | 3 | 2 | 4 | 3 | 2 | ||||
| 179 | BT-RR | Previously | Partial | 3 | 3 | 3 | 3 | 3 | 2 | 3 | 3 | 3 | 4 | 3 | 2 | ||||
| 303 | BT-RR | No | None | 3 | 3 | 1 | 4 | 3 | 1 | 2 | 3 | 3 | 1 | 3 | 3 | 2 | |||
| 342 | BT-RR | No | Complete | 3 | 3 | 3 | 3 | 3 | 3 | 2 | 2 | 2 | 2 | 2 | 2 | ||||
| 380 | BT-RR | No | Complete | 3 | 3 | 1 | 3 | 3 | 2 | 3 | 3 | 2 | 3 | 2 | 1 | ||||
a
Scoring for cytokine staining was as follows: 0, negative; 1, <10% of cells staining positive; 2, 10 to 30% of cells staining positive; 3, 50 to 80% of cells staining positive; and 4, 80 to 100% of cells staining positive. Scoring for cellular infiltrate was as follows: 0, no cellular infiltrate; 1, small granulomas; 2, medium-sized granulomas; and 3, large granulomas.
b
BL-RR, borderline lepromatous leprosy in reversal reaction; BT-RR, borderline tuberculoid leprosy in reversal reaction; MDT, multidrug therapy.