Fig. 1.

CONSORT flow diagram and study design. After enrolment, all participants underwent two preparation sessions (4–6 days and 1 day prior to administration) before being randomised to either the placebo or the psilocybin condition. Drug administration took place on the administration day at 9 a.m. and participants were discharged between 3 a.m. and 5 p.m. on the same day after acute drug effects had completely worn off. Integration of the experience was conducted 2 days, 8 days and 14 days after administration.