Fig. 3.

Association of treatment response with subjective effects. a: Mean values and standard errors of the mean (error bars) on the 5 dimensions altered states of consciousness questionnaire (ASC) in the psilocybin and placebo groups. Treatment groups (blue) differed significantly from Placebo (yellow) on all dimensions. OBN = oceanic boundlessness; AED = anxious ego dissolution; VRS = visual restructuralization; AUA = auditory alterations; VIR = vigilance reduction. 11 dimensions: EXU = experience of unity; SPE = spiritual experiences; BLS = blissfulness; ISF = insightfulness; DEB = disembodiment; ICC = impaired cognition and control; ANX = anxiety; EIM = elementary imagery; CIM = complex imagery; AVS = audio-visual synesthesia; CMP = changed meaning of percepts. b: ASC global intensity scores for responders and non-responders in the psilocybin and placebo groups. Responder and non-responders were defined according to the MADRS response criterion (−50% symptom reduction and/or decrease below the remission threshold) for changes between visit 2 (−5d) and visit 7 (+14d). Distributions were obtained using a gaussian density estimator kernel.