Table 1.
Demographic information of N = 52 participants.
| Psilocybin (N = 26) | Placebo (N = 26) | |
|---|---|---|
| Age | 37.6 (10.9) | 35.9 (9.80) |
| Verbal IQ | 115 (13.1) | 113 (12.1) |
| Years of education | 14.4 (2.52) | 15.0 (2.39) |
| Gender | ||
| Female | 16 (61.5%) | 17 (65.4%) |
| Male | 10 (38.5%) | 9 (34.6%) |
| Ethnicity | ||
| White | 26 (100%) | 23 (88.4%) |
| Black Caribbean | 0 (0%) | 1 (3.8%) |
| Arab | 0 (0%) | 2 (7.7%) |
| Clinical | ||
| MADRS [0–60] | 24.3 (5.07) | 24.1 (7.07) |
| BDI [0–63] | 26.9 (6.70) | 25.8 (9.59) |
| CGI Severity [2–8] | 5.50 (0.58) | 5.54 (0.91) |
| Suicidal ideation [0–5] | 0.53 (0.85) | 0.46 (0.65) |
| Meds at baseline | ||
| Mean (SD) # antidepressants | 0.42 (0.90) | 0.27 (0.45) |
| # of participants with 0 | 19 (73%) | 19 (73%) |
| # of participants with 1 | 5 (19%) | 7 (27%) |
| # of participants with >1 | 2 (7.7%) | 0 (0.0%) |
| Mean (SD) # prescription meds | 0.69 (0.93) | 0.38 (0.70) |
| # of participants with 0 | 14 (54%) | 19 (73%) |
| # of participants with 1 | 8 (31%) | 4 (15%) |
| # of participants with >1 | 4 (15%) | 3 (12%) |
| Prior psychedelic experiences | ||
| # of participants with prior experience | 5 (19.2%) | 11 (42.3%) |
| Mean (SD) life-time occassions with a psychedelic agent from pre-experienced individuals | 2.40 (1.52) | 2.00 (1.00) |
Verbal IQ was assessed by the Multiple-Choice Word Test (MWT-B). Clinical Global Impressions (CGI) provides a clinician-rated impression of overall severity of clinical symptomatology. Suicidal ideation is derived from the intensity of ideation subscale from the Colombia Suicidality Severity Rating Scale (C-SSRS) assessing suicidal thoughts with a scale ranging from zero to five whereas scores greater than three imply acute intentionality. The number of medications used was assessed at the medical screening before discontinuation. Prescription medications include all pharmaceuticals only available on prescription, excluding antidepressant medication which is reported separately. Percentages may not sum up to 100% due to rounding.