Figure 2.

Longitudinal Biomarkers After ICI Comparing Patients With and Without Myocarditis

Average concentration of biomarkers over 12 months beginning at the start of immune checkpoint inhibitor (ICI) therapy for patients with (red) and without (blue) myocarditis for the following biomarkers: (A) alanine aminotransferase (ALT) (reference: 49 IU/L), (B) aspartate aminotransferase (AST) (reference: 34 IU/L), (C) lactate dehydrogenase (LDH) (reference: 240 IU/L), and (D) creatine phosphokinase (CPK) (reference: 240 IU/L). Patients with myocarditis had higher average concentrations of ALT, AST, LDH, and CPK over 12 months after ICI therapy initiation compared with patients without myocarditis.