Table 3.

Peak Biomarker Concentrations and Biomarker Elevation by Myocarditis Grade

	Grade I-II (n = 11)	Grade ≥III (n = 16)
Peak concentration
AST, IU/L	118 (80-171)	202 (106-328)
ALT, IU/L	84 (55-321)	212 (65-342)
LDH, IU/L	347 (321-622)	594 (395-672)
CPK, IU/L	418 (376-1,648)	1,253 (260-2,603)
Biomarker elevation
1-2 biomarkers	0 (0.0)	1 (6.3)
≥3 biomarkers elevated	11 (100.0)	15 (93.7)

Values are median (IQR) or n (%). Myocarditis was graded according to the American Society of Clinical Oncology guidelines. Reference values: ALT, 49 IU/L; AST, 34 IU/L; LDH, 240 IU/L; CPK, 240 IU/L.

Abbreviations as in Table 1.