Table 6.
Description of Patients With/Without Myocarditis After ICI Administration
| Myocarditis (+) (n = 6) | Myocarditis (–) (n = 123) | P Value | |
|---|---|---|---|
| Age, y | 60.3 ± 18.7 | 65.9 ± 10.7 | 0.24 |
| Male | 5 (83.3) | 93 (75.6) | >0.99 |
| Hypertension | 3 (50.0) | 38 (30.9) | 0.38 |
| Diabetes mellitus | 0 (0.0) | 14 (11.4) | >0.99 |
| Dyslipidemia | 0 (0.0) | 16 (13.0) | >0.99 |
| Chronic kidney disease | 2 (33.3) | 38 (30.9) | >0.99 |
| Current or prior smoking | 3 (50.0) | 76 (61.8) | 0.68 |
| Anthracycline | 0 (0.0) | 4 (3.3) | >0.99 |
| Trastuzumab | 0 (0.0) | 3 (2.4) | >0.99 |
| Thoracic irradiation | 1 (16.7) | 20 (16.3) | >0.99 |
| Baseline | |||
| BNP, pg/mL | 8.6 (5.8-28.2) | 20.3 (10.4-35.1) | 0.22 |
| Elevated TnI | 1 (16.7) | 2 (1.6) | 0.14 |
| GLS, % | 18.2 (17.3-18.5) | 17.7 (16.2-19.3) | 0.97 |
| Basal LS, % | 16.7 (12.4-17.7) | 15.8 (14.3-17.8) | 0.84 |
| Mid LS, % | 19.7 (18.9-20.2) | 18.0 (16.3-19.7) | 0.21 |
| Apical LS, % | 20.5 (19.0-21.6) | 20.0 (18.2-22.5) | 0.84 |
| LVEF, % | 65.2 (57.8-66.6) | 65.0 (62.5-67.8) | 0.68 |
| Days 8-14 after ICI administration | |||
| GLS | |||
| Absolute value, % | 17.3 (15.4-18.7) | 17.6 (16.1-18.7) | 0.88 |
| Relative change ≥15% | 0 (0.0) | 9 (7.3) | >0.99 |
| Relative change ≥12.5% | 1 (16.7) | 18 (14.6) | >0.99 |
| Relative change ≥10% | 1 (16.7) | 27 (22.0) | >0.99 |
| Basal LS | |||
| Absolute value, % | 14.7 (11.1-15.7) | 15.7 (13.8-17.3) | 0.14 |
| Relative change ≥15% | 1 (16.7) | 21 (17.1) | >0.99 |
| Relative change ≥12.5% | 3 (50.0) | 26 (21.1) | 0.12 |
| Relative change ≥10% | 4 (66.7) | 34 (27.6) | 0.062 |
| Mid LS | |||
| Absolute value, % | 18.3 (17.1-19.4) | 17.7 (16.2-18.8) | 0.53 |
| Relative change ≥15% | 0 (0.0) | 16 (13.0) | >0.99 |
| Relative change ≥12.5% | 0 (0.0) | 20 (16.3) | 0.59 |
| Relative change ≥10% | 1 (16.7) | 28 (22.8) | >0.99 |
| Apical LS | |||
| Absolute value, % | 20.5 (19.0-22.0) | 19.8 (17.5-21.8) | 0.39 |
| Relative change ≥15% | 0 (0.0) | 24 (19.5) | 0.59 |
| Relative change ≥12.5% | 0 (0.0) | 33 (26.8) | 0.34 |
| Relative change ≥10% | 1 (16.7) | 39 (31.7) | 0.67 |
| LVEF, % | 64.4 (59.3-66.3) | 65.1 (62.6-67.1) | 0.42 |