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. 2022 Dec;13(6):2885–2902. doi: 10.21037/jgo-22-1218

Table 8. Relationship between CHD4 expression and clinicopathological data of patients.

Variable Total, n (%) CHD4 low expression, n (%) CHD4 high expression, n (%) P
Gender 0.520
   Male 66 (66.0) 28 (42.4) 38 (57.6)
   Female 34 (34.0) 17 (50.0) 17 (50.0)
Age (years) 0.092
   <64 55 (55.0) 24 (43.6) 31 (56.4)
   ≥64 45 (45.0) 21 (46.7) 24 (53.3)
Loss of body mass (kg) 0.105
   <5 56 (56.0) 26 (46.4) 30 (53.6)
   ≥5 44 (44.0) 19 (43.2) 25 (56.8)
CEA (ng/mL) 3.778
   ≤5 56 (56.0) 30 (53.6) 26 (46.4)
   >5 44 (44.0) 15 (34.1) 29 (65.9)
Serum albumin (g/L) 1.010
   <35 80 (80.0) 34 (42.5) 46 (57.5)
   ≥35 20 (20.0) 11 (55.0) 9 (45.0)
Tumor size (cm) 5.533
   <3 63 (63.0) 34 (54.0) 29 (46.0)
   ≥3 37 (37.0) 11 (29.7) 26 (70.3)
Differentiation of tumor 4.302
   High to middle differentiation 53 (53.0) 29 (54.7) 24 (45.3)
   Low differentiation 47 (47.0) 16 (34.0) 31 (66.0)
Site of tumor 0.253
   High-medium 36 (36.0) 15 (41.7) 21 (58.3)
   Low 64 (64.0) 30 (46.9) 34 (53.1)
TNM stage 10.725
   I–II 32 (32.0) 22 (68.8) 10 (31.2)
   III–IV 68 (68.0) 23 (33.8) 45 (66.2)
Depth of infiltration 0.049
   In the early (Tis + T1) 21 (21.0) 9 (42.9) 12 (57.1)
   Stage of progression (T2–T4) 79 (79.0) 36 (45.6) 43 (54.4)
Chemotherapy 3.093
   Yes 64 (64.0) 33 (51.6) 31 (48.4)
   No 36 (36.0) 12 (33.3) 24 (66.7)
Distant transfer 0.088
   Yes 8 (8.0) 4 (50.0) 4 (50.0)
   No 92 (92.0) 41 (44.6) 51 (55.4)
Lymph node metastasis 0.042
   Yes 4 (4.0) 2 (50.0) 2 (50.0)
   No 96 (96.0) 43 (44.8) 53 (55.2)
Invasion of nerve 1.584
   Yes 21 (21.0) 12 (57.1) 9 (42.9)
   No 79 (79.0) 33 (41.8) 46 (58.2)

CEA, carcinoembryonic antigen; TNM, tumor/lymph nodes/metastasis; CHD4, chromodomain helicase DNA binding protein 4.