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. 2022 Dec;13(6):3135–3153. doi: 10.21037/jgo-22-1101

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2022 Journal of Gastrointestinal Oncology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The expression of immune checkpoint genes and MHC-related genes in three clusters. (A-D) The expression of PDCD1, CTLA4, LAG3, and CD274 in 3 clusters in TCGA and HCCDB datasets. (E) The expression of MHC-related genes in three clusters in TCGA and HCCDB18 datasets. Kruskal-Wallis test was conducted. ***, P<0.001; ****, P<0.0001. MHC, major histocompatibility complex; TCGA, The Cancer Genome Atlas.