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. 2022 Dec;13(6):3135–3153. doi: 10.21037/jgo-22-1101

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2022 Journal of Gastrointestinal Oncology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Comparison of genomic alterations in three clusters in TCGA dataset. (A) The CNVs of partial genes in 3 clusters. (B-E) The scores of NtAI, LST, HRD-LOH, and HRD in 3 clusters. Kruskal-Wallis test was conducted. (F) The expression of diploid, CNV gain and CNV loss groups in 6 genes. Kruskal-Wallis test was conducted. ns, not significant; *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001. NtAI, number of telomeric regions with allelic imbalance; LST, large-scale transition; HRD, homologous recombination defect; LOH, loss of heterozygosity; TCGA, The Cancer Genome Atlas; CNV, copy number variation.