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. 2022 Dec;13(6):3135–3153. doi: 10.21037/jgo-22-1101

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2022 Journal of Gastrointestinal Oncology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Methylation levels of EMT and DNA repair-related genes in TCGA dataset. (A) The mean beta values of 7 EMT-related genes and 2 DNA repair-related genes in 3 clusters. Kruskal-Wallis test was conducted. (B) Pearson correlation analysis of gene expression with methylation beta values. (C) The methylation beta values of different cg sites in CDH2 in 3 clusters. (D) Pearson correlation analysis of CDH2 gene expression with the beta values of cg sites in 3 clusters. TCGA, The Cancer Genome Atlas; EMT, epithelial-mesenchymal transition. ns, not significant; *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001.