Table 1.

Changes in overall metabolism by GPD2 KO in 4T1 cancer cells as analyzed by RNA-Seq

Metabolism	Pathway	p-value
Carbohydrate metabolism	Glycolysis / Gluconeogenesis	0.34
	Pentose phosphate pathway	0.44
	Pentose and glucuronate interconversions	1
	Fructose and mannose metabolism	*
	Galactose metabolism	1
	Ascorbate and aldarate metabolism	1
	Starch and sucrose metabolism	1
	Amino sugar and nucleotide sugar metabolism	1
	Pyruvate metabolism	0.5
	Glyoxylate and dicarboxylate metabolism	1
	Propanoate metabolism	0.45
	Butanoate metabolism	0.39
	Inositol phosphate metabolism	*
Carbohydrate metabolism	Oxidative phosphorylation	0.52
	Nitrogen metabolism	0.27
	Sulfur metabolism	1
Lipid metabolism	Fatty acid biosynthesis	1
	Fatty acid degradation	0.6
	Synthesis and degradation of ketone bodies	0.19
	Steroid biosynthesis	***
	Primary bile acid biosynthesis	*
	Steroid hormone biosynthesis	0.08
	Glycerolipid metabolism	0.1
	Glycerophospholipid metabolism	**
	Ether lipid metabolism	***
	Sphingolipid metabolism	0.06
	Arachidonic acid metabolism	*
	Linoleic acid metabolism	*
	alpha-Linolenic acid metabolism	*

“*”: p < 0.05; “**”: p < 0.005; “***”: p < 0.0005.