Table 3.
Associations between childhood BMI trajectory and specific obesity-related cancer forms by sexa
| Cancer form | Sex | Childhood BMI trajectory |
||||
|---|---|---|---|---|---|---|
| Below average | Average | Above average | Overweight | Obesityb | ||
| IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | ||
| Colon | Women | 0.88 (0.77 to 1.01) | 1.00 (Referent) | 1.09 (0.97 to 1.23) | 1.12 (0.95 to 1.33) | 1.52 (1.10 to 2.10) |
| Men | 0.86 (0.76 to 0.97) | 1.00 (Referent) | 1.04 (0.93 to 1.16) | 1.13 (0.95 to 1.35) | 1.38 (0.90 to 2.12) | |
| Corpus uteri | Women | 0.98 (0.83 to 1.15) | 1.00 (Referent) | 1.23 (1.07 to 1.42) | 1.49 (1.24 to 1.79) | 3.22 (2.43 to 4.26) |
| Esophagus | Women | 0.90 (0.59 to 1.39) | 1.00 (Referent) | 1.25 (0.87 to 1.78) | 1.51 (0.95 to 2.41) | — |
| Men | 1.15 (0.94 to 1.41) | 1.00 (Referent) | 1.13 (0.93 to 1.39) | 1.46 (1.09 to 1.95) | 1.60 (0.79 to 3.27) | |
| Gastric cardia | Women | 1.18 (0.56 to 2.47) | 1.00 (Referent) | 1.36 (0.71 to 2.60) | 2.28 (1.08 to 4.81) | — |
| Men | 0.85 (0.62 to 1.17) | 1.00 (Referent) | 1.03 (0.77 to 1.37) | 1.02 (0.63 to 1.63) | — | |
| Kidney | Women | 0.91 (0.68 to 1.23) | 1.00 (Referent) | 1.04 (0.81 to 1.35) | 1.33 (0.96 to 1.85) | 1.68 (0.89 to 3.16) |
| Men | 0.90 (0.73 to 1.10) | 1.00 (Referent) | 1.22 (1.02 to 1.46) | 1.17 (0.88 to 1.55) | 1.82 (1.01 to 3.26) | |
| Liver | Women | 1.00 (0.67 to 1.49) | 1.00 (Referent) | 0.92 (0.63 to 1.33) | 1.71 (1.11 to 2.63) | — |
| Men | 0.73 (0.57 to 0.93) | 1.00 (Referent) | 1.03 (0.84 to 1.27) | 1.11 (0.80 to 1.54) | 1.31 (0.60 to 2.88) | |
| Multiple myeloma | Women | 0.88 (0.59 to 1.31) | 1.00 (Referent) | 1.13 (0.81 to 1.58) | 1.03 (0.63 to 1.69) | — |
| Men | 0.84 (0.59 to 1.18) | 1.00 (Referent) | 1.07 (0.79 to 1.46) | 0.85 (0.49 to 1.48) | — | |
| Ovary | Women | 1.06 (0.89 to 1.26) | 1.00 (Referent) | 0.95 (0.80 to 1.11) | 1.17 (0.95 to 1.46) | 2.01 (1.40 to 2.89) |
| Pancreas | Women | 0.93 (0.74 to 1.16) | 1.00 (Referent) | 1.12 (0.92 to 1.36) | 1.21 (0.92 to 1.58) | 1.60 (0.94 to 2.70) |
| Men | 0.78 (0.64 to 0.96) | 1.00 (Referent) | 1.07 (0.90 to 1.27) | 1.33 (1.03 to 1.72) | 1.77 (0.99 to 3.16) | |
| Rectum | Women | 1.07 (0.88 to 1.30) | 1.00 (Referent) | 0.98 (0.82 to 1.18) | 1.18 (0.92 to 1.51) | 0.61 (0.30 to 1.28) |
| Men | 1.06 (0.93 to 1.22) | 1.00 (Referent) | 0.92 (0.80 to 1.06) | 0.97 (0.77 to 1.23) | 0.70 (0.34 to 1.45) | |
| Thyroid | Women | 1.12 (0.76 to 1.67) | 1.00 (Referent) | 1.10 (0.76 to 1.59) | 1.35 (0.85 to 2.14) | 1.87 (0.85 to 4.11) |
| Men | 0.60 (0.33 to 1.11) | 1.00 (Referent) | 0.92 (0.55 to 1.54) | 0.91 (0.41 to 2.06) | — | |
a
Because of the low case number, analyses were not performed for gallbladder and meningioma. BMI = body mass index; CI = confidence interval; IRR = incidence rate ratio.
b
“—” signifies results not presented if <5 cases per regulations on data reporting set by the Danish National Statistics Center.