Table 1.

Molecular Pathophysiology of ICM

Mitochondrial quality control	Regulators	Model
Inflammation	IL-6/ICAM-1/MMP-9/TNF- α/IL-13/TLR/NLRP3	Cardiomyocytes/endothelial cells
Oxidative stress	ROS/SOD/CAT/GSH/ GPX/TreX	Cardiomyocytes/endothelial cells
Cell death	Cyt-C/Smac/HtrA2/Omi/Caspase-3/Caspase-9/RIPK3/MLKL/CypD/CaMKII/	Cardiomyocytes/endothelial cells
Fibrosis	α-SMA/cyto-C/TNF- α/ERK1-2/Smad/TGF-β	Cardiomyocytes
Calcium signal disorder	Cyto-C/SMAC/Omi/HTR2A /AIF/MCU1-MCU2/SERCA/RyR/CaMKII	Cardiomyocytes/endothelial cells