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. 2023 Jan 10;21:4. doi: 10.1186/s12959-022-00448-1

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Evaluation of the PFA-200 COL/ADP closure curves. The flow rate in µl/min is monitored until either complete closure occurs, the measurement exceeds 300 s or the sample volume runs out (which can happen in samples with a low hematocrit). In samples from ECMO-induced aVWS a sudden incline in flow can occur, as seen in the present example for the whole blood sample without VWF after approx. 270 s