Skip to main content
. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Nat Microbiol. 2022 Jul 11;7(8):1210–1220. doi: 10.1038/s41564-022-01162-4

Fig. 6 |. Model for AvciD-based anti-phage activity in bacteria.

Fig. 6 |

Top: before infection, AvcD is maintained in an inactive state by the abundant sRNA, AvcI. Bottom: following infection, AvcD is liberated from AvcI, probably by the cessation of global transcription or the enhanced degradation of AvcI. Active AvcD rapidly depletes available dCMP and dCTP substrates promoting the accumulation of dUMP, via deamination, which probably impairs efficient phage DNA replication and new phage virion production.