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. 2023 Jan 10;15:2. doi: 10.1186/s13073-022-01145-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Mechanosensitive transcriptional regulators are activated in DN glomeruli. a Dot plot displaying the commonly changed transcriptional regulations in both single-cell and bulk RNA-seq data estimated by IPA. b Heatmap showing the activity z scores of transcription factors estimated by SCENIC. c Heatmap showing the log2FC (DN vs. Ctrl) values of MRTF transcriptional target genes in mice glomerular cells. Nonsignificant genes are shown in gray (a, c). d Immunofluorescence staining of the mouse kidney paraffin sections showing the expression and localization of MRTFA and MRTFB in control and DN glomeruli. Glomerular endothelial cells were labeled by EMCN (endomucin), podocytes were labeled by NPHS1 (Nephrin), nuclei were counterstained with HOECHST. Arrows indicate mesangial cells, which were negative for EMCN and NPHS1