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. 2023 Jan 10;15:2. doi: 10.1186/s13073-022-01145-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — MRTF transcriptional target genes are upregulated in DN patients with type 2 diabetes. a Heatmap showing the log2FC (DN vs. Ctrl) values of MRTF transcriptional target genes in microdissected glomeruli from Pima early DN patients. b Pearson correlations between MRTF target gene expression levels and mesangial volumes in Pima early DN patients. c Heatmap showing the log2FC (DN vs. Ctrl) values of MRTF transcriptional target genes in microdissected glomeruli from ERCB patient datasets. Nonsignificant genes are shown in gray. DN, diabetic nephropathy; HT, hypertensive nephropathy; IgA, IgA nephropathy; FSGS, focal segmental glomerulosclerosis; MGN, membranous nephropathy; SLE, lupus nephritis; RPGN, ANCA-associated glomerulonephritis; MCD, minimal change disease