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. 2023 Jan 9;15:10. doi: 10.1186/s13195-022-01121-5

Table 3.

MRI volumes (mean±SEM) of medial temporal lobe–specific regions, according to APOE genotype status and HRT use

Non-E4 E4 PAPOE PHRT PAPOE*HRT
No-HRT (n=591–593) HRT (n=48–50) Total (n=639–643) p-HRT No-HRT (n=345–347) HRT (n=29) Total (n=374–376) p-HRT
Right hippocampus 2360 ±13 2383 ±60 2362 ±13 0.367 2298 ±22 2384 ±37 2304 ±21 0.568 0.903 0.920 0.313
Left hippocampus 2284 ±13 2335 ±57 2288 ±12 0.690 2227 ±22 2333 ±43 2235 ±20 0.378 0.889 0.652 0.345
Right parahippocampal 2670 ±13 2735 ±50 2675 ±13 0.693 2624 ±20 2670 ±52 2628 ±19 0.370 0.430 0.660 0.966
left parahippocampal 2930 ±15 2971 ±46 2933 ±14 0.602 2840 ±20 2946 ±59 2849 ±19 0.801 0.587 0.698 0.302
Right entorhinal 2422 ±15 2444 ±53 2426 ±14 0.943 2378 ±22 2529 ±69 2373 ±22 0.040 a 0.432 0.116 0.074
Left entorhinal 2026 ±12 2014 ±43 2029 ±12 0.426 1967 ±17 2172 ±55 1974 ±17 <0.001 0.106 0.026 a 0.002
Right amygdala 1031 ±07 987 ±21 1029 ±06 0.030a 1002 ±11 1062 ±31 999 ±10 0.063 0.178 0.888 0.005
Left amygdala 1073 ±07 1038 ±23 1072 ±06 0.039a 1039 ±10 1105 ±33 1038 ±10 0.031 a 0.204 0.661 0.003
Ventricular volume 25444 ±814 22262 ±1725 25201 ±763 0.949 24244 ±825 24265 ±3507 24245 ±805 0.860 0.987 0.858 0.920
Right cerebral WMV 10951 ±106 11287 ±351 10977 ±102 0.658 10697 ±140 10584 ±510 10688 ±135 0.291 0.908 0.266 0.576
Left cerebral WMV 11052 ±120 11408 ±372 11080 ±114 0.764 10847 ±146 10581 ±467 10826 ±140 0.961 0.630 0.886 0.842

Mean (mm3) ±SEM of medial temporal lobe–specific MRI brain volumes, according to APOE4 genotype and HRT use. Significant P values for APOE genotype, HRT, and APOE*HRT are shown. MANCOVA model was used. p-HRT within each APOE genotype is calculated using the pairwise comparison of estimated marginal mean with Bonferroni adjustment for multiple comparison. Adjustment of the brain regions to the whole brain volume was carried out before statistical analysis. Age, years of education, marital status, handedness, and CDR were used as covariates. p-significant <0.05. a insignificant after FDR correction for multiple comparison. Bold: significant after FDR correction. WMV white matter volume