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. Author manuscript; available in PMC: 2023 Dec 15.
Published in final edited form as: Mol Cell. 2022 Dec 15;82(24):4647–4663.e8. doi: 10.1016/j.molcel.2022.11.016

Figure 6. Viral integration is associated with 3D-genomic restructuring in HIVE.

Figure 6.

(A) A/B compartment proportions of NeuN- IS in HIV- and HIVE Mg. P, chi-square. (B) Bar graph, dcHiC IS compartment remodeling (HIVE compared to HIV- microglia). X-axis, Mb of genome in 100 kb bins with IS and significantly changed PC1. Y-axis, different compartment switches (HIV- to HIVE), (light blue) A-compartmentalization (DPC1 HIVE-HIV- >0, FDR<0.05), (dark blue) B-compartmentalization (DPC1 HIVE-HIV- <0, FDR<0.05). (C) Violin plot, insulation score at IS in HIV- and HIVE microglia. Wilcoxon rank sum test. (D) Hi-C contact frequency maps of HIVE (top half) and HIV- (bottom half) microglia shown for representative integration sites (gray lines) on chromosome 11. Insulation score plotted below. See also Figure S6.