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. Author manuscript; available in PMC: 2023 Dec 15.
Published in final edited form as: Mol Cell. 2022 Dec 15;82(24):4647–4663.e8. doi: 10.1016/j.molcel.2022.11.016

Figure 7. Viral transcription is associated with microglial activation.

Figure 7.

(A) Rank plot, log normalized expression of each gene in HIV RNA-expressing (RNA+) HIVE. (B) HIV RNA expression mapped onto sub-clustered microglia from HIVE brains with viral transcription (n=5) (C) Gene expression volcano plot (HIVE HIV RNA+ vs. HIV RNA- nuclei). Blue dots mark genes with padj<0.05. (D-E) Bar plots showing biologic process GO enrichment with N dataset genes/total GO category genes indicated for down- and upregulated genes as indicated. Red line FDR=0.05. (F) Pearson correlation, log2(fold change) in gene expression HIV RNA+ vs. RNA- HIVE microglia (Y-axis) and all HIVE microglia vs. HIV- microglia (X-axis) for genes with unadjusted pval<0.05 in at least one comparison. (G) Violin plots, log normalized expression HLA-B and STAT1 in HIV- microglia, HIVE HIV RNA- microglia, and HIVE HIV RNA+ microglia. See also Figure S7.