Table 2.

Preclinical Studies With Single- and Multitargeting Pathogen-specific T Cells

Targeted Pathogen(s)	Manufacturing	References
AF	Ex vivo expansion	Ramadan et al97
AF	IFN-γ capture	Beck et al98
AF	Ex vivo expansion	Zhu et al99
AF	IFN-γ capture and ex vivo expansion	Tramsen et al100
AF	Ex vivo expansion	Gaundar et al101
AF	CD137 selection and ex vivo expansion	Jolink et al102
AF	CD137 selection	Bacher et al103
AF	CD154 or CD137 selection and ex vivo expansion	Stuehler et al104
AF	Ex vivo expansion	Papadopoulou et al123
AF or Aspergillus flavus or Aspergillus terreus or Candida albicans or Candida krusei or Fusarium solani or Fusarium oxysporum or Rhizopus oryzae or Lomentospora prolificans	Ex vivo expansion	Deo et al124
BKV	Ex vivo expansion	Blyth et al108
BKV	Ex vivo expansion	Lamarche et al110
BKV	Ex vivo expansion	Wilhelm et al109
C. albicans	IFN-γ capture and ex vivo expansion	Tramsen et al105
HIV	Ex vivo expansion	Lam et al128
HIV	Ex vivo expansion	Patel et al129
HIV	Ex vivo expansion	Sung et al96
HIV	Ex vivo expansion	Patel et al130
HHV6	Ex vivo expansion	Gerdemann et al112
hMPV	Ex vivo expansion	Tzannou et al116
HPV	Ex vivo expansion	McCormack et al120
HPV	Ex vivo expansion	Van Poelgeest et al119
HPV	Ex vivo expansion	Ramos et al118
HPIV3	Ex vivo expansion	McLaughlin et al115
HPIV3	Ex vivo expansion	Harris et al114
HSV-1	Ex vivo expansion	Ma et al117
Influenza	Ex vivo expansion	Gaundar et al113
MCPyV	Ex vivo expansion	Davies et al131
Mycobacteria spp.	Ex vivo expansion	Patel et al127
Norovirus	Ex vivo expansion	Hanajiri et al122
R. oryzae	CD154 selection, ex vivo expansion, and IFN-γ enrichment	Schmidt et al126
R. oryzae	Ex vivo expansion	Castillo et al125
SARS-CoV-2	Ex vivo expansion	Keller et al132
SARS-CoV-2	Ex vivo expansion	Papayanni et al133
SARS-CoV-2	IFN-γ capture and ex vivo expansion	Cooper et al134
SARS-CoV-2	Ex vivo expansion	Kim et al135
SARS-CoV-2	Ex vivo expansion	Guerreiro et al136
SARS-CoV-2	Ex vivo expansion	Ferreras et al80
SARS-CoV-2	IFN-γ capture and ex vivo expansion	Garcia-Rios et al137
SARS-CoV-2	Ex vivo expansion	Pannikar et al138
VZV	Ex vivo expansion	Blyth et al111
Zika virus	Ex vivo expansion	Hanajiri et al121
CMV, EBV, AdV	Ex vivo expansion	Hanley et al139
CMV, EBV, AdV	Ex vivo expansion	Hanley et al140
CMV, EBV, AdV, BKV	Ex vivo expansion	Dasari et al141
CMV, EBV, AdV, BKV	Ex vivo expansion	Dave et al142
RSV, influenza, PIV, and hMPV	Ex vivo expansion	Vasileiou et al143
CMV, EBV, AdV, BKV, HHV6, VZV, JCV	Ex vivo expansion	Gerdeman et al13
AF, C. albicans, and R. oryzae	IFN-γ capture and ex vivo expansion post	Tramsen et al144
A. terreus, C. krusei, and R. oryzae	Ex vivo expansion ± TNF-α selection	Deo et al124
C. krusei and A. terreus	CD137 selection and ex vivo expansion	Castellano-Gonzalez et al145
AdV, EBV, CMV, C. albicans, and/or AF or AdV, EBV, C. albicans, and AF	CD154 selection and ex vivo expansion	Khanna et al146
EBV, CMV, BKV, and AF	Ex vivo expansion	Papadopoulou et al147

AdV = adenovirus; AF = Aspergillus fumigatus; BKV = BK virus; CMV = cytomegalovirus; EBV = Epstein-Barr virus; HHV6 = human herpesvirus 6; HIV = human immunodeficiency virus; hMPV = human metapneumovirus; HPV = human papillomavirus; HPIV3 = human parainfluenza virus-3; HSV-1 = herpes simplex virus type 1; IFN-γ = interferon-γ; MCPyV = Merkel cell polyomavirus; PIV = parainfluenza virus; RSV = respiratory syncytial virus; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; VZV = varicella zoster.