11. Dexamethasone 0.30 mg/kg compared to dexamethasone 0.15 mg/kg for croup.

Dexamethasone 0.30 mg/kg compared to dexamethasone 0.15 mg/kg for croup
Patient or population: children with croup Setting: emergency department, inpatients and outpatients Intervention: dexamethasone 0.30 mg/kg Comparison: dexamethasone 0.15 mg/kg
Outcomes	Anticipated absolute effects* (95% CI)		Relative effect (95% CI)	№ of participants (studies)	Certainty of the evidence (GRADE)
	Dexamethasone 0.15 mg/kg	Dexamethasone 0.30 mg/kg
Return visits or (re)admissions or both	Study population		RR 0.94 (0.06 to 14.27)	60 (1 RCT)	⊕⊕⊝⊝ Lowa
	34 per 1000	32 per 1000 (2 to 492)
Adverse events	Geelhoed 1995b did not report collecting adverse events data.			60 (1 RCT)	⊕⊕⊝⊝ Lowa,b
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio
GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

^aWe downgraded by two levels for imprecision. The sample size was small (did not meet the optimal information size). The effect estimate included significant benefit, the null effect, and potential harm for 0.30 mg/kg compared to 0.15 mg/kg dexamethasone.
^bWe downgraded by one level for imprecision. Narrative synthesis was conducted, estimates are not precise.