Fig 2. Genome-wide percentile ranking of three selection tests.
The standardized iHS [34] (A, B, C, D, and E), PBS [35] (F, G, H, I, and J), and XP-EHH [33] (K, L, and M) values across the CR1 gene region (50kb upstream and downstream) are plotted for the five population groups (three endemic and two non-endemic). The XP-EHH results were the three endemic population groups versus Mongols. The two non-endemic PBS results (I and J) are plotted from the tests for Indian Austroasiatic populations, Mongols, and Europeans. Dots represent SNPs (iHS and XP-EHH) or windows (PBS) having percentile ranking values equal to or lower than top 0.10 (Y axis) over the Mbp position on chromosome 1 (X axis). The CR1 gene and repeat region on the X axis are indicated as green and mesh bars under the plots, respectively. Across the three methods, here we show SNPs with a percentile ranking equal to or lower than 0.1 for the endemic and non-endemic population groups. In addition, green and purple diamonds indicate the SNPs/windows associated with the CR1 expression level (rs2274567, rs3811381, rs3886100, rs11803956, rs12041437, rs17186848, and rs11803366) and erythrocyte sedimentation rate (rs12034598).