Table 2. Selectivity profile of PTx2-3127 and PTx2-3258 peptides for hNav1.7 versus all other human Nav channels.
| Nav subtype | PTx2-3258 | PTx2-3127 | ||
|---|---|---|---|---|
| IC50 (nM) | Selectivity for hNav1.7 vs hNav1.x (fold) | IC50 (nM) | Selectivity for hNav1.7 vs hNav1.x (fold) | |
| hNav1.1 | 5013 | 1319 | 16,970 | 2459 |
| hNav1.2 | 3399 | 894 | 5040 | 730 |
| rNav1.3 | 14,093 | 3708 | 20,040 | 2904 |
| hNav1.4 | 8877 | 2336 | 11,530 | 1671 |
| hNav1.5 | 38,315 | 10,082 | 137,090 | 19,868 |
| hNav1.6 | 382 | 100 | 608 | 88 |
| hNav1.7 | 3.8 | 1 | 6.9 | 1 |
| hNav1.8 | 43,079 | 11,336 | >150,000 | >20,000 |
| hNav1.9 | 59,443 | 15,642 | >150,000 | >20,000 |
| hERG | 1861 | 496 | 1889 | 272 |